Protein Expression Market by System (Prokaryotic Expression Systems, Mammalian Cell Expression Systems, Insect Cell Expression Systems, Yeast Expression Systems, Cell-Free Expression Systems, Algal-Based Expression Systems), by Product & Services (Reagents, Expression Vectors, Competent Cells, Services, Instruments), by Application (Therapeutic, Industrial, Research), by End User (Pharmaceutical and Biotechnology Companies, Academic Research Institutes, Contract Research Organizations), by Geography (US, Canada, UK, Germany, France, Italy, Spain, China, India, Japan, Brazil, Mexico, South Africa) - Global Market Size, Share, Development, Growth and Demand Forecast, 2013-2023

  • Published: October 2017
  • Report Code: LS11116
  • Available Format: PDF
  • Pages: 231

Protein Expression Market Overview

In 2016, the global protein expression market was valued at $1.4 billion; the market is further projected to reach $3.0 billion by 2023, growing at a CAGR of 11.7% during the forecast period (2017–2023). The term, protein expression, refers to a process by which proteins are altered, synthesized, and regulated in living organisms. When protein research is considered, the term can apply to either laboratory techniques that are required to manufacture proteins or to the object under study. Proteomics study allows the expression of recombinant proteins in various host systems, of which protein expression is a vital part.



The protein expression market, on the basis of system, is categorized into six types: mammalian cell expression systems, prokaryotic expression systems, yeast expression systems, cell-free expression systems, algal-based expression systems, and insect cell expression systems. In 2016, prokaryotic expression systems held the largest share in the market, since they are cheaper when compared to insect cell expression systems and mammalian cell expression systems.

When product and services are taken into consideration, the protein expression market is divided into expression vectors, instruments, competent cells, reagents, and services. During the forecast period, reagents are predicted to hold the largest share in the market due to the large-scale production of antibodies and vaccines and the increasing protein expression research activities.

Protein expression is applicable in the research, industrial, and therapeutic areas. Out of these, therapeutic is projected to hold the largest share in the protein expression market by 2023; this is owed to the fact that there has been a surge in the prevalence of chronic diseases, such as cancer and diabetes, globally, and due to the efficiency of protein therapeutics.

Academic research institutes, contract research organizations, and pharmaceutical and biotechnology companies are the major end-users in the protein expression market, along with some other users. During the forecast period, pharmaceutical and biotechnology companies are expected to hold the largest share of the market. This is attributed to the increasing manufacturing of recombinant therapeutic proteins for disease treatment and the technological advancements in protein expression research.

On the basis of geography, the market is categorized into North America, Asia-Pacific (APAC), Europe, Latin America (LATAM), and Middle East & Africa (MEA). Among these, the protein expression market, in 2016, was dominated by North America, followed by Europe; however, APAC is expected to record the fastest growth during the forecast period. This would be due to the growing prevalence of diseases such as diabetes and cardiovascular diseases, surge in R&D spending, increasing aging population, and rise in the per capita income.

Protein Expression Market Dynamics


Major trends in the protein expression market are the increasing number of acquisitions and rising research activities on recombinant-based protein expression. One of the most powerful molecular biology techniques used in the life sciences sector is the production of recombinant proteins. Abundant production of purified and desired recombinant proteins has extensive application in industrial processes, and it is also useful for diagnosing and treating diseases. Due to the fact that good-quality recombinant proteins can be produced in adequate amount, major players are investing in recombinant-based protein expression.

Growth Drivers

The protein expression market is being driven by various factors, such as aging population, increasing prevalence of chronic diseases, technological advancements, and availability of funding for protein-based research.

Older people are more prone to chronic diseases as compared to younger people, and therefore, they require more regular and intense therapeutic intervention, where protein expression plays a significant role. With the falling birth rate and increasing life expectancy, the aging population is growing, thereby leading to the progress of the protein expression market. According to the United Nations Department of Economic and Social Affairs (UNDESA), the number of people aged 60 or above is projected to grow by 56.0%, worldwide from 901 million in 2015 to 1.4 billion by 2030.


Aspects, such as increasing market consolidations, which are affecting new entrants, and the high cost of protein expression reagents and instruments are hindering the growth of the protein expression market.

Protein expression systems, such as ExpiCHO Expression System Kit by Thermo Fisher Scientific Inc., have high prices, which affect small-scale research laboratories and pharmaceutical industries, and make it hard for them to procure desired high-yield protein products.


In the protein expression market, the emergence of microfluids, along with the untapped market in various emerging countries, provides opportunities to the players looking at investing in it.

The development of high-throughput microfluids platforms for protein expression is expected to have a significant effect on the market, since these provide an insight into the structure and functionality of the biological system. Thus, it is a great opportunity for players to invest in, which would further help in the growth of the protein expression market.

Protein Expression Market Competitive Landscape

The key players in the protein expression market are launching new products and systems to maintain a position of significance.

For example, Thermo Fisher Scientific Inc. launched Thermo Scientific Krios G3i in 2017; the product is designed to deliver the innovative enhancements necessary for the rapid adoption of cryo-EM (a form of transmission electron microscopy). In addition to this, the company also launched Thermo Scientific Glacios, which makes high-performance cryo-EM available to a broad range of scientists for pharmaceutical drug discovery and development.

Some of the other key players operating in the protein expression market are Merck KGaA, Agilent Technologies Inc., Promega Corporation, GenScript Biotech Corporation, Bio-Rad Laboratories Inc., New England Biolabs Inc., QIAGEN N.V., and Lonza Group Ltd.

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