Organ Preservation Market Size & Share Analysis - Emerging Trends, Growth Opportunities, Competitive Landscape, and Forecasts (2025 - 2032)

Organ Preservation Market Trends & Drivers

Technological Innovations in Machine Perfusion Are Key Trend

• The organ preservation market is experiencing a shift from traditional static cold storage to dynamic machine perfusion technologies.
• These advanced systems represent a fundamental transformation in how organs are maintained outside the human body, offering unprecedented opportunities for organ assessment, optimization, and extended preservation times.
• Normothermic machine perfusion systems maintain organs at body temperature (37°C), allowing continuous metabolic activity and real-time viability assessment.
• Hypothermic machine perfusion operates at lower temperatures (4–12 °C) to reduce metabolic demands while providing oxygenation and nutrient delivery.
• Machine perfusion creates the potential for organ viability testing and rehabilitative treatment prior to implantation, enabling clinicians to make informed decisions about organ suitability.
• The technology has demonstrated remarkable success in clinical practice, with the UW solution greatly extending preservation durations for kidneys and livers.
• Recent enhancements incorporate natural trophic factors that have further optimized its efficacy, enabling longer storage with reduced injury.
• These advancements are particularly crucial for marginal or extended criteria donor organs, which represent an increasingly important source of transplantable organs but require careful assessment and optimization before transplantation.
• The FDA has provided detailed IDE guidance for solutions used in hypothermic flushing, transport, and storage of transplant organs.
• They help developers understand required safety and efficacy data, including bench and animal testing, sterility, and pilot study designs.
• Isolated kidney perfusion systems, are classified under regulatory classification 21 CFR §â€¯876.5880, designated as Class II medical devices, requiring compliance with performance standards.
• TransMedics OCS Lung and Liver has earned the FDA premarket approval, underscoring clinical viability.

Rising Incidence of Chronic Diseases Is Biggest Driver

• The global burden of chronic diseases continues to escalate, creating an unprecedented demand for organ transplantation services and, consequently, organ preservation solutions.
• End-stage renal disease, liver cirrhosis, heart failure, and respiratory conditions are reaching epidemic proportions worldwide, driven by aging populations, lifestyle factors, and the increasing prevalence of diabetes and hypertension.
• In September 2024, 89,792 patients were waiting for kidney transplants in the U.S. alone, representing the largest segment of the transplant waiting list.
• The aging demographic particularly impacts organ preservation market growth, as elderly populations experience higher rates of organ failure requiring transplantation.
• The demographic shift intensifies demand for preservation solutions capable of maintaining organ quality from increasingly older donors while ensuring successful outcomes in elderly recipients who may be more vulnerable to complications.
• Furthermore, chronic diseases, such as diabetes and hypertension, are among the leading causes of organ failure, particularly the kidneys, hearts, and livers.
• According to the WHO, more than 41 million deaths are caused by chronic diseases annually.
• In 2023, over 45,000 organ transplants were performed.
• Heart failure impacts nearly 64 million people and is especially common in those aged over 75, intensifying the need for viable organ transplants.

Organ Preservation Market Segmentation Analysis

Solution Analysis

The University of Wisconsin solution category held the largest market share, of 36%, in 2024. This is attributed to the rising adoption of this solution, as it has metabolically inert substrates, including raffinose and lactobionate. These substrates enable less historical damage, improved transplantation outcome, and better physiological function of organs in comparison to other solutions. In addition, it is the most commonly used solution for organ preservation, as it can flush and cold store the liver, kidneys, and pancreas. It is the first intracellular preservation solution and is treated as the standard for the preservation of organs. Moreover, this solution is ideal for preserving liver grafts of humans, for a time period of more than 15 hours. It permits easy transportation of organs over large distances without causing any damage. It is also especially used for liver preservation resulting in a higher success rate of liver transplantation.

The perfadex category will have the highest CAGR, of 8.1%, due to the specialized formulation of the solution to preserve an organ's function and integrity, as it is rich in endothelium during cold ischemic storage as well as flushing before reperfusion and transplantation. Perfadex's proven effectiveness in lung preservation significantly lessens reperfusion injury and enhances graft viability, making it the gold standard for thoracic organ preservation. The increasing number of lung transplants globally, combined with expanding donor criteria that include donation after circulatory death (DCD) donors, fuels demand for this specialized preservation solution.

The solutions analyzed in this report are:

• University of Wisconsin Solution (Largest Category)
• Custodial HTK
• Perfadex (Fastest-Growing Category)

Technique Analysis

The static cold storage category held the largest market share, of 45%, in 2024. This is due to its broad applicability and increasing usage and the presence of various players providing static cold storage services. This technique entails the transportation of a donor's organ on ice and considered a gold standard for preservation in the last decade. Also, this confides in hypothermia to lower the cellular metabolism and demand for oxygen during a prolonged preservation time of organs. SCS effectively reduces metabolic activity through hypothermic conditions, maintaining organ viability for defined periods that enable transportation and transplantation logistics.
The normothermic machine perfusion category will have the highest CAGR, of 8.3%. This is because this technique offers ample nutrition and oxygen for the process of aerobic metabolism and decreases the pro-inflammatory response of the liver and the risk of ischemia damage, supporting the graft healing process. Additionally, the technique is improving the safety of an organ by recreating physiologic conditions by maintaining the average organ temperature consistent during the delivery of important substrates for metabolism, feeding, and oxygenation. Also, for increasing the contingency of long-term graft survival and enhancing the result of marginal donor kidney transplantation, this technique is extensively used. Thus, these factors are expected to boost the market growth in this category in the coming future.

The techniques analyzed in this report are:

• Static Cold Storage (Largest Category)
• Hypothermic Machine Perfusion
• Normothermic Machine Perfusion (Fastest-Growing Category)

Organ Type Analysis

The kidney category held the largest market share, of 60%, in 2024. This is primarily ascribed to the rising number of end-stage renal diseases, which require kidney transplantation for therapeutic treatment. Also, the incidence of kidney failures across the globe is increasing. Kidney disorders usually worsen with time and lead to kidney failure and various other health issues like heart attack and stroke. For instance, an estimated 2 in 1,000 Americans are having end-stage kidney disorders, and approximately 1 in 7 U.S. adults have chronic kidney disease. Moreover, many public awareness campaigns associated with the benefits of surgical treatment are propelling the growth of the market in this category. For instance, the National Kidney Foundation launched 'The Advancing American Kidney Health' initiative for improving the availability of organs accessible for transplant.

The heart category will have the highest CAGR, of 8.6%. This can be attributed to the rising demand for heart transplants. For instance, in 2023, approximately 4,545 heart transplants were performed in the U.S., Italy had around 418 transplants in 2024, and in 2024, around 6,464 organ transplants were performed in Spain. The rising prevalence of heart diseases, with congenital heart disease diagnosed in approximately 1 in every 100 to 110 births globally, underscores the growing need for advanced cardiac preservation solutions.

The organ types analyzed in this report are:

• Kidney (Largest Category)
• Liver
• Lung
• Heart (Fastest-Growing Category)
• Pancreas

End User Analysis

The organ transplant centers category held the largest market share, of 45%, in 2024, and it will have the highest CAGR, of 8.4%, due to the rising number of transplant centers across the world, which are highly equipped with technologically advanced products and the latest techniques. In these facilities, organs can easily be preserved for a long duration and remain viable. Additionally, the increasing awareness among donors and patients about the availability of specialized surgeons and doctors in these centers for carrying out procedures is fostering the growth of the market in this category.

Together with a strong procurement of organs, tissues, and transplantation networks, these centers are engaged in associated research and development that results in technological as well as organ transplantation procedure advancements. Moreover, due to the increasing government supports for the development of advanced biobanking facilities, healthcare providers are also preferring biobanks along with organ transplantation centers for preserving organs. This is one of the most trending facts observed in the bio-preservation sector. These biobanks are government-funded and offer several types of services at a minimal cost.

The end users analyzed in this report are:

• Organ Transplant Centers (largest and Fastest-Growing Category)
• Hospitals
• Organ Banks

Organ Preservation Market Geographical Analysis

North America Organ Preservation Market Size

North America held the largest market share, of 45%, in 2024. This is attributed to the rising need and adoption of organ transplantation due to the occurrence of several chronic disorders in the region and the surging need for preservation solutions for keeping the viability of organs in ex-vivo settings. Additionally, better reimbursement policies, growing acceptance of innovative healthcare technologies, and rising investments for better healthcare infrastructure are fueling the regional market. The Biden Administration signed the Securing the U.S. Organ Procurement and Transplantation Network Act, transforming the organ transplant network by increasing competition in the contracting process and implementing an independent board of directors to strengthen accountability and oversight.

Moreover, the increasing FDA approvals and the rising number of kidney disorders in the U.S. are driving the market growth. For instance, in August 2025, the FDA granted a conditional Investigational Device Exemption (IDE) to TransMedics’ Next-Generation OCS ENHANCE Heart trial.

Canada Organ Preservation Market Size

Canada is witnessing an increase in the number of transplant patients, even though the organ donor number is low. Therefore, to fulfill the gap, the Government of Canada invested USD 2 million for research on innovative organ and tissue donation projects in April 2022. One such project being undertaken by BI Expertise and Ortho BioMed will receive USD 1 million for over two years, from Health Canada to test and develop prototype tools that utilize artificial intelligence for accurately matching organ donors with recipients.

Asia-Pacific Organ Preservation Market Size

Asia-Pacific will have the highest CAGR, of 8.9%, driven by the rapidly improving healthcare infrastructure, increasing government support for organ donation programs, and rising awareness about transplantation as a viable treatment option. Countries like China and Japan have implemented standardized national guidelines for organ donation and transplantation, playing a key role in advancing the market.

The demographic shifts in the Asia-Pacific create substantial market opportunities. According to the United Nations Population Fund (UNFPA), one in four individuals in APAC will be over 60 years of age by 2050, with the population aged 60 years and above expected to triple between 2010 and 2050, reaching 1.3 billion. This aging population, combined with the increasing prevalence of lifestyle-related diseases, drives demand for organ transplants and consequently for advanced preservation solutions.

India Organ Preservation Market Size

India emerges as the fastest-growing in the Asia-Pacific region, supported by government investments in healthcare infrastructure and growing medical tourism for transplant procedures. In February 2023, the Brihanmumbai Municipal Corporation (BMC) in India allocated approximately USD 924 million to improve healthcare services and promote organ donation. Such substantial investments in healthcare infrastructure, combined with awareness campaigns and regulatory improvements, create favorable conditions for organ preservation market expansion, particularly in emerging economies where transplant programs are rapidly developing.

Europe Organ Preservation Market Size

Europe holds the second-largest share in the organ preservation market. The region benefits from well-established transplant networks, standardized protocols across European Union member states, and strong reimbursement frameworks for transplant procedures. Germany represents the largest country market within Europe, driven by its advanced healthcare system and high transplant volumes. France demonstrates the fastest growth rate among European countries, supported by innovative preservation protocols and increasing adoption of machine perfusion technologies.

The European market is characterized by collaborative research initiatives and standardized practices across borders. The implementation of cross-border organ sharing mechanisms through organizations like Eurotransplant enhances organ utilization rates and drives demand for preservation solutions capable of maintaining organ viability during extended transportation times. The region's focus on expanding donor criteria and utilizing marginal organs necessitates advanced preservation technologies, particularly machine perfusion systems that enable organ assessment and optimization.

The geographical breakdown of the market is as follows:

• North America (Largest Regional Market)
  • U.S. (Larger and Faster-Growing Country)
  • Canada
• Europe
  • Germany (Largest Country)
  • U.K. (Fastest-Growing Country)
  • France
  • Italy
  • Spain
  • Rest of Europe
• Asia-Pacific (Fastest-Growing Regional Market)
  • China (Largest Country)
  • India (Fastest-Growing Country)
  • Japan
  • South Korea
  • Australia
  • Rest of APAC
• Latin America
  • Brazil (Largest and Fastest-Growing Country)
  • Mexico
  • Rest of LATAM
• Middle East and Africa
  • Saudi Arabia (Largest Country)
  • South Africa
  • U.A.E. (Fastest-Growing Country)
  • Rest of MEA

Organ Preservation Market Share

The market is fragmented due to the presence of numerous international and regional players competing across different geographies and technologies. Diverse preservation methods, such as static cold storage and machine perfusion; and varying regulatory requirements across countries fragment the market as well. No single company holds a dominant market share, leading to high competition and frequent partnerships, mergers, and acquisitions. Moreover, the rapid technological advancement, specialized companies focusing on specific organ types, and the development of region-specific solutions contribute to market fragmentation.

Organ Preservation Market News

• In January 2025, U.S. Organ Procurement Organizations recovered over 45,000 organs in 2024, marking 14 consecutive years of growth.
• In October 2024, Paragonix Technologies partnered with the Nationwide Organ Recovery Transport Alliance (NORA) to integrate advanced organ preservation devices with commercial flight networks across the U.S.
• In March 2023, the HRSA launched its OPTN Modernization Initiative to strengthen accountability and the performance of the nation's organ transplant system, by focusing on improving the OPTN's governance, technology, and operations.