NGS Sample Preparation Market Report: By Product (Consumables, Automated Workstations, Standalone Automated Instruments, Accessories), Workflow (Library Preparation, Target Enrichment, Sample Extraction/Isolation, Fragmentation, Sample Quantification, Library Quantification, Quality Control, Pooling), Therapeutic Area (Oncology, Infectious Diseases, Human Genetics/Population Genetics), Application (DNA Sequencing, Whole Genome Sequencing, RNA Sequencing, Methylation Sequencing), End User (Hospitals and Clinics, Academic and Research Institutions, Pharmaceutical and Biotechnology Companies) – Global Industry Revenue Estimation and Demand Forecast to 2030

Market Overview

The global NGS sample preparation market size stood at $1,598.8 million in 2021, which is expected to increase to $5,501.2 million by 2030, advancing at a CAGR of 14.7% during 2021–2030. This can be ascribed to the technological advancement in next-generation sequencing (NGS) platforms, the rise in the prevalence of genetic disorders, and the increase in demand for direct-to-consumer genetic testing. Moreover, the surging incidence of infectious diseases also enhances the market growth.

Consumables Account for More Than Half of Total Revenue

The consumables category held the largest revenue share, of over 50%, in the market in 2021, and it is projected to continue witnessing the same trend in the coming years. The high share of consumables in the market is attributed to the increasing demand for testing and related components and equipment, as well as rising relevant research in DNA, RNA, and whole-genome sequencing. Storage plates, low-volume microplates, kits, reagents, pipettes, and other components are some of the essential consumables involved in the sample preparation.

Rising Adoption of Next-Generation Sequencing for Genetic Disorders

For the diagnosis of genetic disorders, next-generation sequencing is widely used. The increasing utilization of NGS in diagnostic laboratories has improved the accuracy and consistency of genetic diagnosis. Prenatal diagnosis and predictive genetic testing are both utilizing advanced genetic diagnostic techniques.

The consistency and effectiveness of diagnostic screening tests are becoming more vital as the number of individuals suffering from several genetic diseases increases. To effectively screen a genetic disorder, faster results with minimal errors are required. The reliability and throughput of sample preparation for genomic sequencing will be enhanced with the automated NGS sample preparation.

Library Preparation Accounts for Largest Revenue

The library preparation category accounted for the largest revenue share in 2021 and is expected to lead the NGS sample preparation market during the forecast period, with a revenue of around $1.5 billion by 2030. This can be ascribed to the growing prevalence of oncology medical conditions and rising emphasis on research procedures. Furthermore, recent advancements in library preparation sequencing kits have created new possibilities for sample sequencing at remarkable levels of coverage. Library preparation, aided by technological advancement, is capable of sequencing nucleic acids and has a much greater sensitivity than other conventional technologies.

Infectious Diseases Are the Fastest-Growing Therapeutic Area

The infectious diseases category, based on therapeutic area, is projected to observe the fastest growth in the market during the forecast period, owing to the rising prevalence of infectious diseases across the world. The next-generation sequencing helps to diagnose infectious diseases, particularly diseases caused by mixed infections, which are a severe issue. To reduce the burden of infectious diseases, submission of multiple samples to laboratories is required in a large number.

Furthermore, advances in next-generation sequencing technology have opened up the possibility of developing a comprehensive strategy for identifying infectious pathogens. NGS has been used to screen and diagnose novel viruses and diseases that escape standard testing. The technology can constantly improve and recognize every pathogen, which may be present in a sample, enabling universal and unbiased pathogen detection. This has resulted in a spike in the use of NGS tools and consumables in general, involving specimen preparation.

DNA Sequencing Is a Major Application Area of NGS

The DNA sequencing category dominated the market, with a revenue share of over 30%, in 2021, and it is expected to continue observing the same trend in the future. DNA sequencing is the major application of next-generation sequencing sample preparation, as it is cost-effective and faster than manual sequencing. Moreover, the need for DNA sequencing in the world is increasing rapidly because it is the technique through which the entire human genome can be sequenced within a single day.

Massive Growth in the Life Sciences Industry Drives the Market

The massive rise in the life sciences industry boosts the market growth. The high adoption of better technologies, expansion of the industry in developing markets, and improvement in technological and scientific capabilities of the industry drive the demand for NGS sample preparation. Furthermore, advancements in the life sciences industry, such as efficient workflow to enhance performance and accuracy, are expected to propel the market.

Academic and Research Institutions Are the Largest Revenue Contributors

Academic and research institutions are expected to contribute the largest revenue, of around $2.2 billion, by 2030 to the NGS sample preparation market. The intense emphasis on R&D is dedicated to the development of new technologies, increase in research grants, and rise in financial support for the improvement and augmentation of NGS products and services.

The COVID-19 pandemic has a favorable impact on the market for NGS sample preparation. There has been an immediate need to rebuild the genomic sequence of COVID-19's etiological agent in order to analyze the virus's structure. Furthermore, using NGS, the testing technique for virus-infected individuals has become simple, allowing healthcare professionals to provide tailored medication for their treatment.

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North America Leads the Market

The North American market accounts for the largest revenue share, and it is expected to witness significant growth during the forecast period, with a CAGR of around 15%. This is because it has a high adoption rate of sequencing technologies and NGS sample preparation sequencing solutions. Furthermore, the increase in the number of NGS-based research and clinical applications and the favorable initiatives taken by the government and private bodies for the development and adoption of NGS technologies help propel the regional market.

On the other hand, the APAC market is projected to witness the fastest growth in the coming years. This can be attributed to the increase in medical research, heightened awareness of these solutions, and the presence of prominent service providers in the region.

Strategic Development of Key Players

Key players in the NGS sample preparation market are engaged in partnerships and acquisitions to gain a competitive edge. For instance:

• In February 2022, C2I Genomics Inc., a cancer intelligence company, and Twist Bioscience Corporation announced a partnership to develop whole-genome cancer reference materials.
• In April 2021, Agilent Technologies Inc. acquired Resolution Bioscience Inc., a player involved in the development and commercialization of next-generation sequencing-based precision oncology solutions, to accelerate its broadly delivered precision oncology testing for patients with NGS-based diagnostic kits, across the world.

Key Players in the Market Are:

• Agilent Technologies Inc.
• Becton, Dickinson and Company
• Beckman Coulter Inc.
• F. Hoffmann-La Roche Ltd.
• Illumina Inc.
• New England Biolabs Inc.
• Integrated DNA Technologies Inc.
• Oxford Nanopore Technologies plc
• Pacific Biosciences of California Inc.

Market Size Breakdown by Segment

The report offers comprehensive market segmentation analysis along with market estimation for the period 2017–2030.

Based on Product

• Consumables
  • Library preparation kits
  • Sample purification kits
  • Sample extraction and isolation kits
  • Target enrichment kits
  • Cleanup and selection kits
  • Microbiome DNA enrichment kits
• Automated Workstations
  • Open systems
  • Closed systems
• Standalone Automated Instruments
  • Fragment analyzers
  • Nucleic acid extraction/isolation systems
  • DNA selection instruments
  • DNA/RNA shearing instruments
  • Template preparation instruments
  • Ultrasonicators/Sonicators
• Accessories

Based on Workflow

• Library Preparation
• Target Enrichment
• Sample Extraction/Isolation
• Fragmentation
• Sample Quantification
• Library Quantification
• Quality Control (QC)
• Pooling

Based on Therapeutic Area

• Oncology
• Infectious Diseases
• Human Genetics/Population Genetics

Based on Application

• DNA Sequencing
• Whole Genome Sequencing
• RNA Sequencing
• Methylation Sequencing

Based on End User

• Hospitals and Clinics
• Academic and Research Institutions
• Pharmaceutical and Biotechnology Companies

Geographical Analysis

• North America
  • U.S.
  • Canada
• Europe
  • U.K.
  • Germany
  • France
  • Spain
  • Italy
• Asia-Pacific
  • China
  • India
  • Japan
  • South Korea
  • Australia
• Latin America
  • Brazil
  • Mexico
• Middle East and Africa
  • Saudi Arabia
  • South Africa