NGS Sample Preparation Market Size & Share Analysis - Trends, Drivers, Competitive Landscape, and Forecasts (2025 - 2030)

NGS Sample Preparation Market Size

NGS Sample Preparation Market Trends & Growth Drivers

Adoption of NGS for Genetic Disorders Is Key Trend

• For the diagnosis of genetic disorders, next-generation sequencing is widely used.
• The increasing utilization of NGS in diagnostic laboratories has improved the accuracy and consistency of genetic diagnosis. Prenatal diagnosis and predictive genetic testing are both utilizing advanced genetic diagnostic techniques.
• The consistency and effectiveness of diagnostic screening tests are becoming more vital as the number of individuals suffering from several genetic diseases increases.
• To effectively screen a genetic disorder, faster results with minimal errors are required.
• The reliability and throughput of sample preparation for genomic sequencing will be enhanced with the automated NGS sample preparation.

Massive Growth in the Life Sciences Industry Drives Market

• NGS techniques are widely used for diagnosis, drug development, or discovery, in the growing life sciences and healthcare industries, to deliver the next level of healthcare solutions.
• The remarkable growth in genomic profiling and analysis has given access to numerous avenues in the pharmaceutical and diagnostic sectors, especially in the area of precision medicine.
• Similarly, the widespread use of NGS in diagnostic laboratories has enhanced the accuracy of genetic diagnostics with high consistency.
• Genomic study in healthcare research is one of the key applications of the NGS.
• Where advanced genetic diagnostic techniques are being used for predictive genetic testing and prenatal diagnosis.
• According to a report published in the National Library of Medicine, about 1 in 200,000 people in the U.S. are diagnosed with syndrome A each year.
• An estimated 15,000 people worldwide were diagnosed with syndrome B in 2020, globally.
• An estimated 12,000 people worldwide died from syndrome C in the same year.
• As the genetic disorder prevalence is increasing, the efficiency and consistency of diagnostic screening tests are becoming more crucial.
• Faster results with minimum errors are required to effectively screen a genetic disorder.
• Automated NGS sample preparation enhances the consistency and throughput of the sample preparation for genetic sequencing.
• Thus, the high adoption of better technologies, expansion of the industry in developing markets, and improvement in technological and scientific capabilities of the industry drive the demand for NGS sample preparation.
• Furthermore, advancements in the life sciences industry, such as efficient workflow to enhance performance and accuracy, are expected to propel the market growth.

Stringent Regulatory Standards Hamper Market Growth

• The reduction in human error, increased throughput, and less time have revolutionized the overall process of automated NGS sample preparation.
• As per the U.S. Food and Drug Administration (FDA), all test elements used in NGS, such as software, reagents, consumables, and instruments, should all be fully documented and described.
• Additionally, the materials used for library preparation and laboratory equipment, such as automated liquid handlers, should be standard and recognized.
• Moreover, pertaining to input and sample preparation for NGS, storage, processing, handling, and preservation, all should be well established and documented.

NGS Sample Preparation Market Analysis

Product Analysis

The consumables category holds the largest revenue share, of 55%, in the market in 2024, and it is projected to continue witnessing the same trend in the coming years. The high share of consumables in the market is attributed to the increasing demand for testing and related components and equipment, as well as rising relevant research in DNA, RNA, and whole-genome sequencing. Storage plates, low-volume microplates, kits, reagents, pipettes, and other components are some of the essential consumables involved in the sample preparation.

Automated workstations will have the highest CAGR as these devices offer a host of advantages in the laboratory. The biggest among them is high throughput; compared to manual systems, automated workstations can produce 10 times more sample volume in a given period. Moreover, being automated, they reduce the chances of human error and offer higher accuracy and consistency, while also decreasing operational expenses for users. Another advantage is their ability to simplify complex steps in sample preparation, such as quality control and library preparation.

These product types are considered:

• Consumables (Largest Category)
  • Library preparation kits
  • Sample purification kits
  • Sample extraction and isolation kits
  • Target enrichment kits
  • Cleanup and selection kits
  • Microbiome DNA enrichment kits
• Standalone Automated Instruments (Fastest-Growing Category)
  • Fragment analyzers
  • Nucleic acid extraction/isolation systems
  • DNA selection instruments
  • DNA/RNA shearing instruments
  • Template preparation instruments
  • Ultrasonicators/sonicators
• Accessories and Components

Workflow Analysis

The library preparation category accounts for the largest revenue share in 2024 and is expected to lead the NGS sample preparation market during the forecast period. This can be ascribed to the growing prevalence of oncology medical conditions and rising emphasis on research procedures. Furthermore, recent advancements in library preparation sequencing kits have created new possibilities for sample sequencing at remarkable levels of coverage. Library preparation, aided by technological advancement, is capable of sequencing nucleic acids and has a much greater sensitivity than other conventional technologies.

Target enrichment is the fastest-growing category, with 16% CAGR, during this decade. This process is used for isolating specific regions the genome, as per the exact application, which makes it prized in the areas of precision medicine, genetic testing, and oncology.

The following workflows have been analyzed:

• Library Preparation (Largest Category)
• Target Enrichment (Fastest-Growing Category)
• Sample Extraction/Isolation
• Fragmentation
• Sample Quantification
• Library Quantification
• Quality Control (QC)
• Pooling

Usage Area Analysis

Oncology accounts for the largest share, of 35%, due to the increasing implementation of DNA sequencing in clinical utilization. Moreover, the rising number of research initiatives identifying clinical implementation as the primary end goal will continue to bolster this market. NGS has become a new standard of care in the field of oncology. The increasing number of cancer cases globally has contributed to the growth of the NGS sample preparation market in this category. It helps to detect novel and rare mutations present in the tumor sample. It has been adopted widely in clinical oncology to advance personalized cancer treatment. As per a survey, around 75.6% of the oncologists in the U.S. use NGS to guide cancer treatment.

The infectious diseases category is projected to observe healthy growth in the market during the forecast period, owing to the rising prevalence of infectious diseases across the world. The next-generation sequencing helps to diagnose infectious diseases, particularly diseases caused by mixed infections, which are a severe issue. To reduce the burden of infectious diseases, submission of multiple samples to laboratories is required in a large number.

Furthermore, advances in next-generation sequencing technology have opened up the possibility of developing a comprehensive strategy for identifying infectious pathogens. NGS has been used to screen and diagnose novel viruses and diseases that escape standard testing. The technology can constantly improve and recognize every pathogen, which may be present in a sample, enabling universal and unbiased pathogen detection. This has resulted in a spike in the use of NGS tools and consumables in general, involving specimen preparation.

The segment is categorized as below:

• Oncology (Largest Category)
• NIPT
• Drug Discovery (Fastest-Growing Category)
• Microbiology
• Infectious Diseases
• Germline Disease Risk Evaluation
• Applied Markets

Application Analysis

The DNA sequencing category dominates the market in 2024, and it is expected to witness the fastest growth in the future, of 17%. DNA sequencing is the major application of next-generation sequencing sample preparation, as it is cost-effective and faster than manual sequencing. Moreover, the need for DNA sequencing in the world is increasing rapidly because it is the technique through which the entire human genome can be sequenced within a single day.

We studied the following applications:

• DNA Sequencing (Largest and Fastest-Growing Category)
• Whole Genome Sequencing
• RNA Sequencing
• Methylation Sequencing
• Others

End User Analysis

Academic and research institutions are expected to contribute the most revenue, of USD 2.2 billion, by 2030 to the NGS sample preparation market. The intense emphasis on R&D is dedicated to the development of new technologies, increase in research grants, and rise in financial support for the improvement and augmentation of NGS products and services.

The COVID-19 pandemic has a favorable impact on the market for NGS sample preparation, especially in regard to research institutions. There has been an immediate need to rebuild the genomic sequence of COVID-19's etiological agent in order to analyze the virus's structure. Furthermore, using NGS, the testing technique for virus-infected individuals has become simple, allowing healthcare professionals to provide tailored medication for their treatment.

Pharmaceutical and biotechnology companies are expected to witness the highest CAGR during the forecast period. This is primarily attributed to the growing popularity of precision medicine, which impels pharma & biotech companies to sample individual patients’ DNA to create tailored treatments. NGS also speeds up genetic analysis, enabling these companies to bring new drugs faster to the market. Additionally, this procedure is increasingly being utilized for standard sample preparation for clinical trials, where any regulatory oversight can push the whole process years back.

The end users covered are as follows:

• Hospitals and Clinics
• Academic and Research Institutions (Largest Category)
• Pharmaceutical and Biotechnology Companies (Fastest-Growing Category)
• Others

Regional Analysis

• The North American market accounts for the largest revenue share, of 45%.
• The growing need for novel therapeutic strategies for infectious diseases and cancer, the rising geriatric population, the escalating application of NGS in precision medicine, the increasing R&D expenditure, and the presence of major industry players in the region are some of the key factors driving the market.
• Moreover, the surging demand for NGS samples in applications based on DNA sequencing, whole-genome sequencing, and RNA sequencing propels the growth of the market.
• According to the World Bank, the number of people aged 65 years and above in the U.S. is expected to reach 84.2 million by 2050, while Canada will have a geriatric population of 11.4 million by mid-century.
• As aged adults experience a higher risk of chronic disease, there is an increasing demand for novel therapies, to provide adequate-quality healthcare to patients.
• This may lead to a rise in the disease research aetiology through techniques such as NGS, thereby boosting the demand for associated products, including samples.
• The APAC market is projected to witness the fastest growth in the coming years, of 18%.
• This can be attributed to the increase in medical research, heightened awareness of these solutions, and the presence of prominent service providers in the region.
• The growth in the APAC market is expected to be further enhanced by other factors such as an increase in healthcare awareness, a steady economy leading to a higher focus on genomic research, and the widespread adoption of genome sequencing as the standard of care.

Below is the geographical breakdown of this market:

• North America (Largest Regional Market)
  • U.S. (Larger and Faster-Growing Country Market)
  • Canada
• Europe
  • U.K.
  • Germany (Largest and Fastest-Growing Country Market)
  • France
  • Spain
  • Italy
  • Rest of Europe
• Asia-Pacific (APAC) (Fastest-Growing Regional Market)
  • China (Fastest-Growing Country Market)
  • India
  • Japan (Largest Country Market)
  • South Korea
  • Australia
  • Rest of APAC
• Latin America (LATAM)
  • Brazil (Largest and Fastest-Growing Country Market)
  • Mexico
  • Rest of LATAM
• Middle East and Africa (MEA)
  • Saudi Arabia (Largest and Fastest-Growing Country Market)
  • South Africa
  • Rest of MEA

NGS Sample Preparation Market Share

The NGS sample preparation market is consolidated as only a few major life sciences and biotechnology companies hold significant shares. This is because only they have the expertise, advanced equipment, finances, and R&D capability to produce such complicated solutions and advance them regularly. This is why only they are able to comply with the strict regulatory guidelines, which raise the entry barriers for emerging companies with limited budget and technical expertise. Additionally, major hospitals and diagnostic laboratories have long-term supply contracts with the major players, which further discourages newcomers.

NGS Sample Preparation Market News

• In October 2024, Illumina Inc. launched its MiSeq i100 Series of benchtop next-generation sequencers. The he MiSeq i100 Plus System enables full 100 million single-end reads, while the MiSeq i100 System enables 25 million single-end reads at once.
• In September 2024, F. Hoffmann-La Roche Ltd. opened its Pharma Research and Early Development Center in Basel, Switzerland. Built at a cost of CHF 1.2 billion, this twin-building campus houses 150 laboratories and workstations for 1,800 scientists.
• In August 2024, Agilent Technologies Inc. announced a partnership with Sangon Biotech to enhance DNA/RNA research and clinical application.
• In April 2024, New England Biolabs Inc. launched Monarch Mag kit for Viral DNA/RNA extraction.