NGS Sample Preparation Market Analysis

Next-Generation Sequencing Sample Industry Insights

Product Analysis

The consumables category holds the largest revenue share, of 55%, in the market in 2024, and it is projected to continue witnessing the same trend in the coming years. The high share of consumables in the market is attributed to the increasing demand for testing and related components and equipment, as well as rising relevant research in DNA, RNA, and whole-genome sequencing. Storage plates, low-volume microplates, kits, reagents, pipettes, and other components are some of the essential consumables involved in the sample preparation.

Automated workstations will have the highest CAGR as these devices offer a host of advantages in the laboratory. The biggest among them is high throughput; compared to manual systems, automated workstations can produce 10 times more sample volume in a given period. Moreover, being automated, they reduce the chances of human error and offer higher accuracy and consistency, while also decreasing operational expenses for users. Another advantage is their ability to simplify complex steps in sample preparation, such as quality control and library preparation.

These product types are considered:

• Consumables (Largest Category)
  • Library preparation kits
  • Sample purification kits
  • Sample extraction and isolation kits
  • Target enrichment kits
  • Cleanup and selection kits
  • Microbiome DNA enrichment kits
• Standalone Automated Instruments (Fastest-Growing Category)
  • Fragment analyzers
  • Nucleic acid extraction/isolation systems
  • DNA selection instruments
  • DNA/RNA shearing instruments
  • Template preparation instruments
  • Ultrasonicators/sonicators
• Accessories and Components

Workflow Analysis

The library preparation category accounts for the largest revenue share in 2024 and is expected to lead the NGS sample preparation market during the forecast period. This can be ascribed to the growing prevalence of oncology medical conditions and rising emphasis on research procedures. Furthermore, recent advancements in library preparation sequencing kits have created new possibilities for sample sequencing at remarkable levels of coverage. Library preparation, aided by technological advancement, is capable of sequencing nucleic acids and has a much greater sensitivity than other conventional technologies.

Target enrichment is the fastest-growing category, with 16% CAGR, during this decade. This process is used for isolating specific regions the genome, as per the exact application, which makes it prized in the areas of precision medicine, genetic testing, and oncology.

The following workflows have been analyzed:

• Library Preparation (Largest Category)
• Target Enrichment (Fastest-Growing Category)
• Sample Extraction/Isolation
• Fragmentation
• Sample Quantification
• Library Quantification
• Quality Control (QC)
• Pooling

Usage Area Analysis

Oncology accounts for the largest share, of 35%, due to the increasing implementation of DNA sequencing in clinical utilization. Moreover, the rising number of research initiatives identifying clinical implementation as the primary end goal will continue to bolster this market. NGS has become a new standard of care in the field of oncology. The increasing number of cancer cases globally has contributed to the growth of the NGS sample preparation market in this category. It helps to detect novel and rare mutations present in the tumor sample. It has been adopted widely in clinical oncology to advance personalized cancer treatment. As per a survey, around 75.6% of the oncologists in the U.S. use NGS to guide cancer treatment.

The infectious diseases category is projected to observe healthy growth in the market during the forecast period, owing to the rising prevalence of infectious diseases across the world. The next-generation sequencing helps to diagnose infectious diseases, particularly diseases caused by mixed infections, which are a severe issue. To reduce the burden of infectious diseases, submission of multiple samples to laboratories is required in a large number.

Furthermore, advances in next-generation sequencing technology have opened up the possibility of developing a comprehensive strategy for identifying infectious pathogens. NGS has been used to screen and diagnose novel viruses and diseases that escape standard testing. The technology can constantly improve and recognize every pathogen, which may be present in a sample, enabling universal and unbiased pathogen detection. This has resulted in a spike in the use of NGS tools and consumables in general, involving specimen preparation.

The segment is categorized as below:

• Oncology (Largest Category)
• NIPT
• Drug Discovery (Fastest-Growing Category)
• Microbiology
• Infectious Diseases
• Germline Disease Risk Evaluation
• Applied Markets

Application Analysis

The DNA sequencing category dominates the market in 2024, and it is expected to witness the fastest growth in the future, of 17%. DNA sequencing is the major application of next-generation sequencing sample preparation, as it is cost-effective and faster than manual sequencing. Moreover, the need for DNA sequencing in the world is increasing rapidly because it is the technique through which the entire human genome can be sequenced within a single day.

We studied the following applications:

• DNA Sequencing (Largest and Fastest-Growing Category)
• Whole Genome Sequencing
• RNA Sequencing
• Methylation Sequencing
• Others

End User Analysis

Academic and research institutions are expected to contribute the most revenue, of USD 2.2 billion, by 2030 to the NGS sample preparation market. The intense emphasis on R&D is dedicated to the development of new technologies, increase in research grants, and rise in financial support for the improvement and augmentation of NGS products and services.

The COVID-19 pandemic has a favorable impact on the market for NGS sample preparation, especially in regard to research institutions. There has been an immediate need to rebuild the genomic sequence of COVID-19's etiological agent in order to analyze the virus's structure. Furthermore, using NGS, the testing technique for virus-infected individuals has become simple, allowing healthcare professionals to provide tailored medication for their treatment.

Pharmaceutical and biotechnology companies are expected to witness the highest CAGR during the forecast period. This is primarily attributed to the growing popularity of precision medicine, which impels pharma & biotech companies to sample individual patients’ DNA to create tailored treatments. NGS also speeds up genetic analysis, enabling these companies to bring new drugs faster to the market. Additionally, this procedure is increasingly being utilized for standard sample preparation for clinical trials, where any regulatory oversight can push the whole process years back.

The end users covered are as follows:

• Hospitals and Clinics
• Academic and Research Institutions (Largest Category)
• Pharmaceutical and Biotechnology Companies (Fastest-Growing Category)
• Others