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Idiopathic Pulmonary Fibrosis (IPF) Pipeline Analysis

P&S Market Research-Idiopathic Pulmonary Fibrosis Therapeutics Market report

Global Idiopathic Pulmonary Fibrosis (IPF) Pipeline Analysis, 2016 - Clinical Trials & Results, Patent, Designation, Collaboration, and Other Developments

Published: February 2017
Report Code: LS10753
Available Format: pdf
Pages: 183

Pipeline Overview

Idiopathic pulmonary fibrosis (IPF) is referred to as progressive and chronic interstitial pneumonia without known cause. Pulmonary fibrosis is a disease in which tissue profound in lungs becomes stiff and dense over time. The scar tissue formation is known as fibrosis. As the fibrosis progresses and tissue become darker, lungs can't properly move oxygen into the bloodstream, which result in oxygen deficiency in brain and other organs.

IPF usually affects older adults and middle-aged people and it has no cure till now. The major cause of death in IPF’s patients is respiratory failure. Pulmonary hypertension, heart failure, pulmonary embolism, pneumonia and lung cancer are the other causes of the death for IPF patient. With the progress in research for IPF, it is now more quickly diagnosed and many drugs are also being discovered for its treatment. This will improve the quality of life of patients and will also increase their lifespan.

Bronchoscopy and surgical lung biopsy are used as testing procedures. In Bronchoscopy, lymphocytosis in bronchoalveolar lavage fluid is absent which is observed for the diagnosis. The best sample for characteristic usual interstitial pneumonia from other idiopathic interstitial pneumonias is surgical lung biopsy. The treatment for IPF as optimal medical cure has yet to be identified. This creates ample growth opportunities for pharmaceutical companies, as there is very low competition due to lack of approved drugs.

Current treatment approaches for IPF include the management and assessment of comorbid conditions per present practice guidelines, including obstructive sleep apnea, chronic obstructive pulmonary disease, coronary artery disease and gastroesophageal reflux disease. Other strategies for IPF include surgery and pharmacotherapy. This further fuels the demand for the development of therapeutics for IPF treatment.

 

GLOBAL IPF PIPELINE SPLIT BY TARGET (2016)

Pipeline Analysis

The IPF pipeline is very strong with a total of 97 drug candidates. Pharma giant such as Asahi Kasei Corporation, Merck & Co., Inc., Biogen and Sanofi are involved in the development of the IPF therapeutics. The IPF pipeline comprised of 97 product candidates, of which one is in Phase III stage, 15 are in Phase II stage, 12 are in Phase I stage, 39 are in Pre-clinical stage, and seven are in discovery stage.

SM04646 is under Phase I stage of development by Samumed, LLC for the treatment of IPF. The drug candidate is a small molecule that acts as Wnt pathway modulator. Samumed is using the technology for development of small molecule that modulate Wnt pathway. The technology is not a stem cell therapy, instead focusing on the modulation of the Wnt pathway that recovers and restores the health of diseased tissues and presents significant opportunities in regenerative therapeutics.

Competitive Landscape

Several companies are involved in IPF with their products in different phases. The only Phase III IPF drug candidate is being developed by Asahi Kasei Pharma Corporation. The IPF pipeline drug candidates of Merck & Co., Inc., Bristol-Myers Squibb Company, F. Hoffmann-La Roche AG and FibroGen, Inc. are in Phase II stage of development. Bristol-Myers Squibb Company is also having its IPF pipeline drug candidates in different clinical stages, including two drugs in Phase II and one drug in Phase I. Some of the key players developing drug candidates for the treatment of IPF  are Bristol-Myers Squibb Company, F. Hoffmann-La Roche Ltd., Merck & Co., Inc., Global Blood Therapeutics, Inc., Asahi Kasei Corporation, Beijing Tide Pharmaceutical Co., Limited, FibroGen, Inc., Chong Kun Dang Pharmaceutical Corp., Galapagos NV, Kadmon Holdings, Inc., MediciNova, Inc., and Promedior, Inc.

Scope for Customization

P&S Market Research offers customization as per specific business requirements of clients. Illustrative customization within the scope of this report includes:

  • Market Forecast – Market analysis and forecast for the drug candidates in the latest stage of development
  • Company Profiles – Wider company coverage in terms of detailed analysis or additional company profiles

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