Peptides are the small molecules composed of aminoacids which are connected with each other with peptide bond. Peptides play an important role in various anabolic and catabolic biological processes. They play a key role in cell signaling pathways, hormonal systems, enzymatic systems immune system and various other important functions of the body. Increasing prevalence of various chronic diseases such as cancer, and diabetes mellitus is the major factor that has led to the development of peptides. Peptide molecules are mainly useful in the drug development for the treatment of various diseases such as cancer, diabetes mellitus, hypertension, gastrointestinal diseases, autoimmune disorders (mainly in multiple sclerosis, rheumatoid arthritis). The various peptides being investigated in clinical trials for the treatment of chronic diseases are peptide hormones, cyclic peptides, depsipeptides, dipeptides, glycopeptides, lipopeptides, neuropeptides, oligopeptides, opioid peptides, natriuretic peptides. Beijing Doing Biomedical Co., Ltd., is in the process of clinical development of MUC1-peptide-DC-CTL for the treatment of gastric cancer. Peptide drugs used in the market for the treatment of various diseases include Nesiritide, Ceruletide, Bentiromide, Exenatide, Gonadorelin, Enfuvirtide, Vancomycin. Some of the peptides which are pipeline development are LY 2510924, UV1 synthetic peptide vaccine, SVN53-67/M57-KLH Peptide Vaccine, BB MPI 03, MELITAC 12.1 Peptide Vaccine.T.he companies having a pipeline of peptide molecules are Amgen, Inc., GlaxoSmithKline Plc, F. Hoffmann-La Roche AG, Tapimmune Inc., Immune Response BioPharma, Inc., AstraZeneca Plc and others.
The report provides a comprehensive understanding of the pipeline activities covering all drug candidates under various stages of development, with detailed analysis of pipeline and clinical trials. Pipeline analysis of drugs by phases includes product description and development activities including information about clinical results, designations, collaborations, licencing, grants, technology and others.