Published: July 2017
Report Code: LS11103
Category : Pharmaceuticals
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Diabetic foot ulcer is a serious complication of diabetes and can be defined as the ulceration in foot along with neuropathy or peripheral artery disease of the lower limb in diabetic patients. Currently, the prevalence of diabetic foot ulcer in diabetic population of the U.S. stands at 4% to 10%. Among diabetic foot ulcer patients, it is estimated that majority (around 60% to 80%) of foot ulcer are capable to heal, while 10% to 15% remain active and around 5% to 24% of them can lead to limb amputation within a period of 6-18 months. Diabetic foot ulcer is associated with neuropathic wounds as well as neuroischemic wounds. The neuropathic wounds are more likely to heal whereas, neuroischemic wounds take longer to heal, and can more often lead to amputation of the respective limb. Many studies have reported that, approximately 85% of all amputations performed in diabetic patients are caused by diabetic foot ulcer. Duration of diabetes and age of the diabetic patients further increase the risk of diabetic foot ulcer and limb amputation.
Considerable growth is expected in the diabetic foot ulcer therapeutic pipeline, attributed to increasing prevalence of diabetes. According to the World Health Organization, the prevalence of diabetes among adults over 18 years of age, has risen from 4.7% in 1980 to 8.5% in 2014, in the U.S. Funds received or raised from various non-profit organizations such as, American Podiatric Medical Association and PAN Association, are being used to support the development of therapeutic pipeline of the diabetic foot ulcer. Many technological advancements are also contributing towards the development of diabetic foot ulcer therapeutics pipeline.
As of July 2017, the diabetic foot ulcer pipeline comprises of approximately 27 drug candidates in different stages of development.
Number of DIABETIC FOOT ULCER drug candidates under Development (2017)
Some of the key players developing drugs for the treatment of diabetic foot ulcer include Lakewood Amedex, Inc., Edixomed Ltd., CardioVascular BioTherapeutics Inc. and others.
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